Clinical Trial Finder

Inclusion Criteria:

1. Observational group.

• - Initial diagnosis of a primary salivary gland carcinoma in the head and neck region (no squamous cell carcinomas) - Specimen collection from the center of the tumor when the primary tumor is sufficiently large without that the pathological assessment is impaired.

2. Control group 1.

• - Initial diagnosis of a benign salivary gland tumor in the head and neck region.

• - Specimen collection from the center of the tumor when the primary tumor is sufficiently large without that the pathological assessment is impaired.

3. Control group 2.

• - functional diseases of the nose or ear (patients with the indication for functional ear surgery and rhinoplasty) - Specimen collection with sufficiently large resectate during a functional nose surgery.

for all groups:

• - Willingness of patients to collect blood, saliva and stool and consent to the preservation of all samples for study purposes.

• - Age ≥ 18 years.

• - sufficient cognitive ability of the patients to understand the purpose of the study and to understand the purpose of the study and agree to it.

Exclusion Criteria:

• - Distant metastasis at the time of diagnosis and simultaneous second cancers, i.e. at study inclusion.

• - Malignancy in the last 5 years regardless of location (except basal cell carcinoma or cis of the uterine cervix) - Carcinomas for which specimen collection is not possible or likely without compromising the compromise the pathological evaluation.

• - Persistent drug or medication abuse.

• - Patients who are unable or unwilling to comply with protocol and to be treated.

• - Patients who are represented by a legal guardian.

- Patients who are not suitable for participation in the study due to a language barrier

Arms

: Observational Arm

Initial diagnosis of primary salivary gland carcinoma in the head and neck region

: Control Group 1

Initial diagnosis of a benign salivary gland tumor in the head and neck region

: Control Group 2

Healthy control group. Functional diseases of the nose or ear (patients with the indication for functional ear surgery and rhinoplasty) without salivary gland tumor.

Interventions

Other: - Sampling

Evaluation of immune characteristics by using patient's stool, saliva and blood samples.