Clinical Trial Finder
Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers
Study Purpose
This phase II/III compares the standard therapy (chemotherapy plus cetuximab) versus adding bevacizumab to standard chemotherapy, versus combination of just bevacizumab and atezolizumab in treating patients with head and neck cancer that has spread to other places in the body (metastatic or advanced stage) or has come back after prior treatment (recurrent). Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Cetuximab is in a class of medications called monoclonal antibodies. It binds to a protein called EGFR, which is found on some types of cancer cells. This may help keep cancer cells from growing. Cisplatin and carboplatin are in a class of chemotherapy medications known as platinum-containing compounds. They work by killing, stopping, or slowing the growth of cancer cells. Docetaxel is in a class of chemotherapy medications called taxanes. It stops cancer cells from growing and dividing and may kill them. The addition of bevacizumab to standard chemotherapy or combination therapy with bevacizumab and atezolizumab may be better than standard chemotherapy plus cetuximab in treating patients with recurrent/metastatic head and neck cancers.
Recruitment Criteria
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.
An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.
Searching Both is inclusive of interventional and observational studies.
Inclusion Criteria:
- - Patient must have histologically confirmed squamous cell carcinoma of the head and
neck (HNSCC) (excluding SCC of salivary glands, Epstein-Barr virus [EBV]-associated
nasopharynx and skin)
- Patient must have measurable disease as defined by Response Evaluation Criteria in
Solid Tumors (RECIST) version (v)1.1.
Measurements must be obtained within 4 weeks prior to randomization.- - Patient must have disease progression after prior therapy with an immune checkpoint
inhibitor (ICI) in the first-line setting for recurrent/metastatic disease.
Patient must have received first-line immune checkpoint inhibition for at least 6 weeks. Patients who have recurred or progressed within 12 weeks of immune checkpoint inhibition administered in the definitive setting for locally advanced disease (for e.g., in the context of a clinical trial) will also be eligible if local therapies are not feasible.- - Prior combination immunotherapies are permitted, but patient must not have had prior
antiangiogenic treatment (e.g., bevacizumab, ziv-aflibercept, ramucirumab, sorafenib,
sunitinib, pazopanib, regorafenib, lenvatinib, etc.).
Patient must have completed any prior investigational therapy at least 28 days prior to randomization. NOTE: Patients who received platinum/taxanes in the locally-advanced or recurrent/metastatic setting and did not progress for at least 4 months thereafter, will be eligible for this study. Patients who received cetuximab in the locally-advanced setting and did not progress for at least 4 months thereafter, will also be eligible for this study.- - Patient must not have a history of >= grade 3 immune-related adverse event on prior
ICI therapy (except those that could be managed with steroids [e.g., dermatologic
toxicity, asymptomatic elevation of pancreatic enzymes, etc.]) and ICI could
eventually be resumed.
Patients who developed grade 3 endocrinopathies but are now stable on hormone supplementation and/or a daily prednisone dose of =< 10 mg (or equivalent doses of another glucocorticoid), will be permitted on this trial.- - Patient must not have a history of thrombosis (e.g., pulmonary embolism or deep venous
thrombosis) currently requiring therapeutic anticoagulation (prophylactic use of
anticoagulation is allowed)
- Patient must not be receiving chronic daily treatment with aspirin (> 325 mg/day) or
non-steroidal anti-inflammatory agents (NSAID's) known to inhibit platelet function.
The use of anti-platelet agents [e.g., dipyridamole (Persantine), ticlopidine (Ticlid), clopidogrel (Plavix)] is allowed only if patient is not receiving concurrent aspirin or NSAID's known to inhibit platelet function.- - NOTE: Enrolling centers should test for PD-L1 CPS preferably using the SP263
assay.
Where this is not feasible, using their preferred Clinical Laboratory Improvement Act (CLIA)-certified or similar assay will be accepted. It is preferred for standard of care (SOC) PD-L1 assessments to be done on post-first line ICI samples if available, but SOC PD-L1 assessments on pre-ICI samples will be accepted for eligibility.- - Patient must not have a severe infection within 4 weeks prior to randomization,
including, but not limited to, hospitalization for complications of infection,
bacteremia, or severe pneumonia.
Patients must not have active tuberculosis.- - Patient must not have an active autoimmune disease that requires systemic treatment
within 2 years prior to randomization.
Patients who are receiving replacement therapy for adrenal or pituitary insufficiency will not be excluded.- - Patient must not have received any live vaccine within 30 days prior to randomization
and while participating in the study (and continue for 5 months after the last dose of
atezolizumab on Arm C).
Live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, rabies, bacillus Calmette-Guerin (BCG), and typhoid (oral) vaccine. Patients are permitted to receive inactivated vaccines and any non-live vaccines including those for the seasonal influenza and coronavirus disease 2019 (COVID-19) (Note: intranasal influenza vaccines, such as Flu-Mist (registered trademark) are live attenuated vaccines and are not allowed). If possible, it is recommended to separate study drug administration from vaccine administration by about a week (primarily, in order to minimize an overlap of adverse events.- - Patient must have the ability to understand and the willingness to sign a written
informed consent document.
Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible.- - Patients with a history of hepatitis C virus (HCV) infection must have been treated
and cured.
For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load.- - Patients with treated brain metastases are eligible if follow-up brain imaging after
central nervous system (CNS)-directed therapy shows no evidence of progression.
Patients must not have untreated brain metastases or leptomeningeal disease.- - Patients must not have uncontrolled pleural effusion, pericardial effusion, or ascites
requiring recurrent drainage procedures (once monthly or more frequently).
Patients may have indwelling catheters (e.g., PleurX [registered trademark])- - Patient must not receive any other chemotherapy, immunotherapy, antitumor hormonal
therapy (excluding contraceptives and replacement steroids), radiation therapy, or
experimental medications while on protocol treatment.
Symptomatic lesions (e.g., bone metastases or metastases causing nerve impingement) amenable to palliative radiotherapy should be treated prior to randomization and patients must be recovered from the effects of radiation (there is no required minimum recovery period.- - Patient must not have any other disease, metabolic dysfunction, physical examination
finding, or clinical laboratory finding that contraindicates the use of the agents
used in this protocol, may affect the interpretation of the results, or may render the
patient at high risk from treatment complications.
- Patient must not have a history of abdominal fistula, gastrointestinal (GI) perforation, intra-abdominal abscess, or active GI bleeding within 6 months prior to randomizationTrial Details
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.
Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.
Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.
Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.
The person who is responsible for the scientific and technical direction of the entire clinical study.
Category of organization(s) involved as sponsor (and collaborator) supporting the trial.
The disease, disorder, syndrome, illness, or injury that is being studied.
PRIMARY OBJECTIVES:
- I. To evaluate progression-free survival (PFS) of patients treated with chemotherapy plus
cetuximab, chemotherapy plus bevacizumab, and atezolizumab plus bevacizumab.
(Phase II)- II.
To evaluate the overall survival (OS) of patients treated with chemotherapy plus cetuximab to
the superior arm from the phase II portion of the protocol.
(Phase III) SECONDARY OBJECTIVES:- II. To evaluate the toxicity of each arm of treatment.
IMAGING OBJECTIVES:- II. To determine if 18FDG-PET/CT and CT neck imaging biomarkers at baseline will predict
treatment response at nine to twelve weeks post the initiation of treatment, PFS, and OS.
EXPLORATORY OBJECTIVE:- I. To establish the correlation between 18F-FDG PET and CT neck radiomics features and PD-L1
expressions (Low versus high - defined as CPS < 20 versus CPS >= 20).
OUTLINE: This is a randomized phase II trial followed by a randomized phase III trial. PHASE II: Patients are randomized to 1 of 3 arms. ARM A: Patients receive cetuximab intravenously (IV) over 60-120 minutes on days 1, 8, and 15 of each cycle, docetaxel IV over 1 hour on day 1 or days 1 and 8 of each cycle, and cisplatin IV or carboplatin IV on day 1 or days 1 and 8 of each cycle. Treatment repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity. Patients then receive cetuximab IV over 60-120 minutes on days 1, 8, and 15 or days 1 and 15 of each cycle of maintenance therapy. Cycles repeat every 21 days for 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo a CT scan, a PET scan, and/or magnetic resonance imaging (MRI) throughout the trial. Patients may undergo echocardiography (ECHO) during screening. ARM B: Patients receive bevacizumab IV over 30-90 minutes on day 1 of each cycle, docetaxel IV over 1 hour on day 1 or days 1 and 8 of each cycle, and cisplatin IV or carboplatin IV on day 1 or days 1 and 8 of each cycle. Treatment repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity. Patients then receive bevacizumab IV over 30-60 minutes on day 1 of each cycle of maintenance therapy. Cycles repeat every 21 days for 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo a CT scan, a PET scan, and/or MRI throughout the trial. Patients may undergo ECHO during screening. ARM C: Patients receive bevacizumab IV over 30-90 minutes on day 1 and atezolizumab over 30-60 minutes on day 1 of each cycle. Cycles repeat every 21 days for 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo a CT scan, a PET scan, and/or MRI throughout the trial. Patients may undergo ECHO during screening. PHASE III: Patients are randomized to 1 of 2 arms. ARM A: Patients receive cetuximab IV over 60-120 minutes on days 1, 8, and 15 of each cycle, docetaxel IV over 1 hour on day 1 or days 1 and 8 of each cycle, and cisplatin IV or carboplatin IV on day 1 or days 1 and 8 of each cycle. Treatment repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity. Patients then receive cetuximab IV over 60-120 minutes on days 1, 8, and 15 or days 1 and 15 of each cycle of maintenance therapy. Cycles repeat every 21 days for 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo a CT scan, a PET scan, and/or MRI throughout the trial. Patients may undergo ECHO during screening. ARM B: Patients receive treatment as in Arm B or C above based on results of the Phase II trial. Patients undergo blood sample collection throughout the study. After completion of study treatment, patients are followed up at 30 days and then every 3 months if patient is < 2 years from randomization and every 6 months if patient is 2-5 years from randomization.Arms
Active Comparator: Phase II, Arm A (Cetuximab, Docetaxel, Cisplatin, Carboplatin)
Patients receive cetuximab IV over 60-120 minutes on days 1, 8, and 15 of each cycle, docetaxel IV over 1 hour on day 1 or days 1 and 8 of each cycle, and cisplatin IV or carboplatin IV on day 1 or days 1 and 8 of each cycle. Treatment repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity. Patients then receive cetuximab IV over 60-120 minutes on days 1, 8, and 15 or days 1 and 15 of each cycle of maintenance therapy. Cycles repeat every 21 days for 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo a CT scan, a PET scan, and/or MRI throughout the trial. Patients may undergo ECHO during screening. Patients undergo blood sample collection throughout the study.
Experimental: Phase II, Arm B(Docetaxel, Cisplatin/Carboplatin, Bevacizumab)
Patients receive bevacizumab IV over 30-90 minutes on day 1 of each cycle, docetaxel IV over 1 hour on day 1 or days 1 and 8 of each cycle, and cisplatin IV or carboplatin IV on day 1 or days 1 and 8 of each cycle. Treatment repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity. Patients then receive bevacizumab IV over 30-60 minutes on day 1 of each cycle of maintenance therapy. Cycles repeat every 21 days for 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo a CT scan, a PET scan, and/or MRI throughout the trial. Patients may undergo ECHO during screening. Patients undergo blood sample collection throughout the study.
Experimental: Phase II, Arm C (Bevacizumab, Atezolizumab)
Patients receive bevacizumab IV over 30-90 minutes on day 1 and atezolizumab over 30-60 minutes on day 1 of each cycle. Cycles repeat every 21 days for 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo a CT scan, a PET scan, and/or MRI throughout the trial. Patients may undergo ECHO during screening. Patients undergo blood sample collection throughout the study.
Experimental: Phase III, Arm A (Cetuximab, Docetaxel, Cisplatin/Carboplatin)
Patients receive cetuximab IV over 60-120 minutes on days 1, 8, and 15 of each cycle, docetaxel IV over 1 hour on day 1 or days 1 and 8 of each cycle, and cisplatin IV or carboplatin IV on day 1 or days 1 and 8 of each cycle. Treatment repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity. Patients then receive cetuximab IV over 60-120 minutes on days 1, 8, and 15 or days 1 and 15 of each cycle of maintenance therapy. Cycles repeat every 21 days for 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo a CT scan, a PET scan, and/or MRI throughout the trial. Patients may undergo ECHO during screening. Patients undergo blood sample collection throughout the study.
Experimental: Phase III, Arm B (Chemotherapy, Bevacizumab, Atezolizumab)
Patients receive treatment as in Arm B or C above based on results of the Phase II trial.
Interventions
Biological: - Atezolizumab
Given IV
Biological: - Bevacizumab
Given IV
Procedure: - Biospecimen Collection
Undergo blood sample collection
Drug: - Carboplatin
Given IV
Biological: - Cetuximab
Given IV
Drug: - Cisplatin
Given IV
Procedure: - Computed Tomography
Undergo CT scan
Drug: - Docetaxel
Given IV
Procedure: - Echocardiography
Undergo ECHO
Procedure: - Magnetic Resonance Imaging
Undergo MRI
Procedure: - Positron Emission Tomography
Undergo PET scan
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Active, not recruiting
Address
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205
Status
Active, not recruiting
Address
Epic Care-Dublin
Dublin, California, 94568
Status
Active, not recruiting
Address
Epic Care Partners in Cancer Care
Emeryville, California, 94608
Status
Active, not recruiting
Address
Contra Costa Regional Medical Center
Martinez, California, 94553-3156
Status
Recruiting
Address
Stanford Cancer Institute Palo Alto
Palo Alto, California, 94304
Site Contact
Site Public Contact
[email protected]
650-498-7061
Status
Recruiting
Address
VA Palo Alto Health Care System
Palo Alto, California, 94304
Site Contact
Site Public Contact
800-455-0057
Status
Suspended
Address
Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut, 06418
Status
Recruiting
Address
Smilow Cancer Hospital Care Center-Fairfield
Fairfield, Connecticut, 06824
Site Contact
Site Public Contact
[email protected]
203-785-5702
Status
Recruiting
Address
Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury, Connecticut, 06033
Site Contact
Site Public Contact
[email protected]
203-785-5702
Status
Suspended
Address
Smilow Cancer Hospital Care Center at Greenwich
Greenwich, Connecticut, 06830
Status
Suspended
Address
Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut, 06437
Status
Recruiting
Address
Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut, 06105
Site Contact
Site Public Contact
[email protected]
203-785-5702
Status
Recruiting
Address
Yale University
New Haven, Connecticut, 06520
Site Contact
Site Public Contact
[email protected]
203-785-5702
Status
Recruiting
Address
Yale-New Haven Hospital North Haven Medical Center
North Haven, Connecticut, 06473
Site Contact
Site Public Contact
[email protected]
203-785-5702
Status
Recruiting
Address
Smilow Cancer Hospital-Orange Care Center
Orange, Connecticut, 06477
Site Contact
Site Public Contact
[email protected]
203-785-5702
Status
Suspended
Address
Smilow Cancer Hospital Care Center at Long Ridge
Stamford, Connecticut, 06902
Status
Suspended
Address
Smilow Cancer Hospital-Torrington Care Center
Torrington, Connecticut, 06790
Status
Recruiting
Address
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, 06611
Site Contact
Site Public Contact
[email protected]
203-785-5702
Status
Suspended
Address
Smilow Cancer Hospital-Waterbury Care Center
Waterbury, Connecticut, 06708
Status
Recruiting
Address
Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut, 06385
Site Contact
Site Public Contact
[email protected]
203-785-5702
Status
Recruiting
Address
Helen F Graham Cancer Center
Newark, Delaware, 19713
Site Contact
Site Public Contact
[email protected]
302-623-4450
Status
Recruiting
Address
Medical Oncology Hematology Consultants PA
Newark, Delaware, 19713
Site Contact
Site Public Contact
[email protected]
302-623-4450
Status
Recruiting
Address
MedStar Washington Hospital Center
Washington, District of Columbia, 20010
Site Contact
Site Public Contact
202-877-8839
Status
Recruiting
Address
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, 33146
Site Contact
Site Public Contact
305-243-2647
Status
Recruiting
Address
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, 33442
Site Contact
Site Public Contact
305-243-2647
Status
Recruiting
Address
Broward Health Medical Center
Fort Lauderdale, Florida, 33316
Site Contact
Site Public Contact
[email protected]
302-651-5572
Status
Recruiting
Address
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, 33136
Site Contact
Site Public Contact
305-243-2647
Status
Recruiting
Address
UM Sylvester Comprehensive Cancer Center at Kendall
Miami, Florida, 33176
Site Contact
Site Public Contact
305-243-2647
Status
Recruiting
Address
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida, 33324
Site Contact
Site Public Contact
305-243-2647
Status
Recruiting
Address
Emory University Hospital Midtown
Atlanta, Georgia, 30308
Site Contact
Site Public Contact
888-946-7447
Status
Recruiting
Address
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322
Site Contact
Site Public Contact
404-778-1868
Status
Recruiting
Address
Hawaii Cancer Care - Westridge
'Aiea, Hawaii, 96701
Site Contact
Site Public Contact
[email protected]
808-539-2273
Status
Recruiting
Address
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu, Hawaii, 96813
Site Contact
Site Public Contact
[email protected]
808-524-6115
Status
Recruiting
Address
Queen's Cancer Cenrer - POB I
Honolulu, Hawaii, 96813
Site Contact
Site Public Contact
808-532-0315
Status
Recruiting
Address
Queen's Medical Center
Honolulu, Hawaii, 96813
Site Contact
Site Public Contact
808-545-8548
Status
Recruiting
Address
Queen's Cancer Center - Kuakini
Honolulu, Hawaii, 96817
Site Contact
Site Public Contact
808-531-8521
Status
Recruiting
Address
Saint Luke's Cancer Institute - Boise
Boise, Idaho, 83712
Site Contact
Site Public Contact
[email protected]
208-381-2774
Status
Recruiting
Address
Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho, 83619
Site Contact
Site Public Contact
[email protected]
208-381-2774
Status
Recruiting
Address
Saint Luke's Cancer Institute - Meridian
Meridian, Idaho, 83642
Site Contact
Site Public Contact
[email protected]
208-381-2774
Status
Recruiting
Address
Saint Luke's Cancer Institute - Nampa
Nampa, Idaho, 83686
Site Contact
Site Public Contact
[email protected]
208-381-2774
Status
Recruiting
Address
Saint Luke's Cancer Institute - Twin Falls
Twin Falls, Idaho, 83301
Site Contact
Site Public Contact
[email protected]
208-381-2774
Status
Recruiting
Address
Rush - Copley Medical Center
Aurora, Illinois, 60504
Site Contact
Site Public Contact
[email protected]
630-978-6212
Status
Recruiting
Address
John H Stroger Jr Hospital of Cook County
Chicago, Illinois, 60612
Site Contact
Site Public Contact
312-864-5204
Status
Recruiting
Address
University of Illinois
Chicago, Illinois, 60612
Site Contact
Site Public Contact
312-355-3046
Status
Recruiting
Address
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637
Site Contact
Site Public Contact
[email protected]
773-702-8222
Status
Recruiting
Address
Carle at The Riverfront
Danville, Illinois, 61832
Site Contact
Site Public Contact
[email protected]
800-446-5532
Status
Recruiting
Address
Carle Physician Group-Effingham
Effingham, Illinois, 62401
Site Contact
Site Public Contact
[email protected]
800-446-5532
Status
Recruiting
Address
Ingalls Memorial Hospital
Harvey, Illinois, 60426
Site Contact
Site Public Contact
[email protected]
708-915-4673
Status
Recruiting
Address
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, 61938
Site Contact
Site Public Contact
[email protected]
800-446-5532
Status
Recruiting
Address
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois, 60451
Site Contact
Site Public Contact
[email protected]
773-702-8222
Status
Recruiting
Address
University of Chicago Medicine-Orland Park
Orland Park, Illinois, 60462
Site Contact
Site Public Contact
[email protected]
773-702-8222
Status
Recruiting
Address
Carle Cancer Center
Urbana, Illinois, 61801
Site Contact
Site Public Contact
[email protected]
800-446-5532
Status
Recruiting
Address
Rush-Copley Healthcare Center
Yorkville, Illinois, 60560
Site Contact
Site Public Contact
[email protected]
630-978-6212
Status
Recruiting
Address
Mary Greeley Medical Center
Ames, Iowa, 50010
Site Contact
Site Public Contact
515-956-4132
Status
Recruiting
Address
McFarland Clinic - Ames
Ames, Iowa, 50010
Site Contact
Site Public Contact
[email protected]
515-239-4734
Status
Recruiting
Address
Mission Cancer and Blood - Ankeny
Ankeny, Iowa, 50023
Site Contact
Site Public Contact
515-282-2921
Status
Recruiting
Address
McFarland Clinic - Boone
Boone, Iowa, 50036
Site Contact
Site Public Contact
515-956-4132
Status
Recruiting
Address
Mercy Cancer Center-West Lakes
Clive, Iowa, 50325
Site Contact
Site Public Contact
[email protected]
515-358-6613
Status
Recruiting
Address
Mission Cancer and Blood - West Des Moines
Clive, Iowa, 50325
Site Contact
Site Public Contact
515-241-3305
Status
Recruiting
Address
Greater Regional Medical Center
Creston, Iowa, 50801
Site Contact
Site Public Contact
[email protected]
515-358-6613
Status
Recruiting
Address
Iowa Methodist Medical Center
Des Moines, Iowa, 50309
Site Contact
Site Public Contact
515-241-6727
Status
Recruiting
Address
Mission Cancer and Blood - Des Moines
Des Moines, Iowa, 50309
Site Contact
Site Public Contact
515-241-3305
Status
Recruiting
Address
Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314
Site Contact
Site Public Contact
[email protected]
515-358-6613
Status
Recruiting
Address
Mission Cancer and Blood - Laurel
Des Moines, Iowa, 50314
Site Contact
Site Public Contact
515-241-3305
Status
Recruiting
Address
McFarland Clinic - Trinity Cancer Center
Fort Dodge, Iowa, 50501
Site Contact
Site Public Contact
515-956-4132
Status
Recruiting
Address
McFarland Clinic - Jefferson
Jefferson, Iowa, 50129
Site Contact
Site Public Contact
515-956-4132
Status
Recruiting
Address
McFarland Clinic - Marshalltown
Marshalltown, Iowa, 50158
Site Contact
Site Public Contact
515-956-4132
Status
Recruiting
Address
Mercy Medical Center-West Lakes
West Des Moines, Iowa, 50266
Site Contact
Site Public Contact
[email protected]
515-358-6613
Status
Recruiting
Address
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland, 21201
Site Contact
Site Public Contact
800-888-8823
Status
Recruiting
Address
Greater Baltimore Medical Center
Baltimore, Maryland, 21204
Site Contact
Site Public Contact
443-849-3706
Status
Recruiting
Address
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287
Site Contact
Site Public Contact
[email protected]
410-955-8804
Status
Recruiting
Address
UPMC Western Maryland
Cumberland, Maryland, 21502
Site Contact
Site Public Contact
240-964-1400
Status
Recruiting
Address
UMass Memorial Medical Center - University Campus
Worcester, Massachusetts, 01655
Site Contact
Site Public Contact
[email protected]
508-856-3216
Status
Recruiting
Address
Mercy Hospital
Coon Rapids, Minnesota, 55433
Site Contact
Site Public Contact
[email protected]
952-993-1517
Status
Recruiting
Address
Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407
Site Contact
Site Public Contact
[email protected]
952-993-1517
Status
Recruiting
Address
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, 55416
Site Contact
Site Public Contact
[email protected]
952-993-1517
Status
Recruiting
Address
Regions Hospital
Saint Paul, Minnesota, 55101
Site Contact
Site Public Contact
[email protected]
952-993-1517
Status
Suspended
Address
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, 03756
Status
Recruiting
Address
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87106
Site Contact
Site Public Contact
[email protected]
505-925-0348
Status
Recruiting
Address
Memorial Medical Center - Las Cruces
Las Cruces, New Mexico, 88011
Site Contact
Site Public Contact
[email protected]
575-556-6545
Status
Recruiting
Address
Southeastern Medical Oncology Center-Clinton
Clinton, North Carolina, 28328
Site Contact
Site Public Contact
[email protected]
919-587-9084
Status
Recruiting
Address
Southeastern Medical Oncology Center-Goldsboro
Goldsboro, North Carolina, 27534
Site Contact
Site Public Contact
[email protected]
919-587-9084
Status
Recruiting
Address
Southeastern Medical Oncology Center-Jacksonville
Jacksonville, North Carolina, 28546
Site Contact
Site Public Contact
[email protected]
910-587-9084
Status
Recruiting
Address
Miami Valley Hospital South
Centerville, Ohio, 45459
Site Contact
Site Public Contact
[email protected]
937-528-2900
Status
Recruiting
Address
Miami Valley Hospital
Dayton, Ohio, 45409
Site Contact
Site Public Contact
[email protected]
937-528-2900
Status
Recruiting
Address
Premier Blood and Cancer Center
Dayton, Ohio, 45409
Site Contact
Site Public Contact
937-276-8320
Status
Recruiting
Address
Dayton Physician LLC - Englewood
Dayton, Ohio, 45415
Site Contact
Site Public Contact
[email protected]
937-528-2900
Status
Recruiting
Address
Miami Valley Hospital North
Dayton, Ohio, 45415
Site Contact
Site Public Contact
[email protected]
937-528-2900
Status
Recruiting
Address
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio, 45005-1066
Site Contact
Site Public Contact
[email protected]
937-528-2900
Status
Recruiting
Address
Miami Valley Cancer Care and Infusion
Greenville, Ohio, 45331
Site Contact
Site Public Contact
937-569-7515
Status
Recruiting
Address
Kettering Medical Center
Kettering, Ohio, 45429
Site Contact
Site Public Contact
[email protected]
937-528-2900
Status
Recruiting
Address
Trinity's Tony Teramana Cancer Center
Steubenville, Ohio, 43952
Site Contact
Site Public Contact
888-874-7000
Status
Recruiting
Address
Toledo Clinic Cancer Centers-Toledo
Toledo, Ohio, 43623
Site Contact
Site Public Contact
800-444-3561
Status
Recruiting
Address
Upper Valley Medical Center
Troy, Ohio, 45373
Site Contact
Site Public Contact
[email protected]
937-528-2900
Status
Recruiting
Address
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104
Site Contact
Site Public Contact
[email protected]
405-271-8777
Status
Suspended
Address
Providence Cancer Institute Clackamas Clinic
Clackamas, Oregon, 97015
Status
Recruiting
Address
Providence Newberg Medical Center
Newberg, Oregon, 97132
Site Contact
Site Public Contact
[email protected]
503-215-2614
Status
Recruiting
Address
Providence Portland Medical Center
Portland, Oregon, 97213
Site Contact
Site Public Contact
[email protected]
503-215-2614
Status
Recruiting
Address
Providence Saint Vincent Medical Center
Portland, Oregon, 97225
Site Contact
Site Public Contact
[email protected]
503-215-2614
Status
Recruiting
Address
UPMC Altoona
Altoona, Pennsylvania, 16601
Site Contact
Site Public Contact
[email protected]
Status
Recruiting
Address
UPMC-Heritage Valley Health System Beaver
Beaver, Pennsylvania, 15009
Site Contact
Site Public Contact
[email protected]
412-389-5208
Status
Recruiting
Address
UPMC Hillman Cancer Center at Butler Health System
Butler, Pennsylvania, 16001
Site Contact
Site Public Contact
[email protected]
412-389-5208
Status
Active, not recruiting
Address
UPMC Camp Hill
Camp Hill, Pennsylvania, 17011
Status
Recruiting
Address
Carlisle Regional Cancer Center
Carlisle, Pennsylvania, 17015
Site Contact
Site Public Contact
[email protected]
Status
Recruiting
Address
UPMC Hillman Cancer Center - Passavant - Cranberry
Cranberry Township, Pennsylvania, 16066
Site Contact
Site Public Contact
[email protected]
412-389-5208
Status
Recruiting
Address
UPMC Hillman Cancer Center Erie
Erie, Pennsylvania, 16505
Site Contact
Site Public Contact
[email protected]
412-389-5208
Status
Recruiting
Address
UPMC Cancer Center at UPMC Horizon
Farrell, Pennsylvania, 16121
Site Contact
Site Public Contact
[email protected]
Status
Recruiting
Address
UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg, Pennsylvania, 15601
Site Contact
Site Public Contact
724-838-1900
Status
Recruiting
Address
Oncology Hematology Associates
Greenville, Pennsylvania, 16125
Site Contact
Site Public Contact
[email protected]
Status
Suspended
Address
UPMC Hillman Cancer Center in Greenville/UPMC Horizon
Greenville, Pennsylvania, 16125
Status
Recruiting
Address
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg, Pennsylvania, 17109
Site Contact
Site Public Contact
[email protected]
717-724-6765
Status
Recruiting
Address
IRMC Cancer Center
Indiana, Pennsylvania, 15701
Site Contact
Site Public Contact
[email protected]
412-389-5208
Status
Recruiting
Address
UPMC-Johnstown/John P. Murtha Regional Cancer Center
Johnstown, Pennsylvania, 15901
Site Contact
Site Public Contact
814-534-4724
Status
Recruiting
Address
UPMC Cancer Center at UPMC McKeesport
McKeesport, Pennsylvania, 15132
Site Contact
Site Public Contact
412-647-8073
Status
Recruiting
Address
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Mechanicsburg, Pennsylvania, 17050
Site Contact
Site Public Contact
[email protected]
412-389-5208
Status
Recruiting
Address
Forbes Hospital
Monroeville, Pennsylvania, 15146
Site Contact
Site Public Contact
412-858-7746
Status
Recruiting
Address
UPMC Hillman Cancer Center - Monroeville
Monroeville, Pennsylvania, 15146
Site Contact
Site Public Contact
[email protected]
412-389-5208
Status
Recruiting
Address
UPMC Hillman Cancer Center in Coraopolis
Moon, Pennsylvania, 15108
Site Contact
Site Public Contact
[email protected]
412-389-5208
Status
Recruiting
Address
UPMC Hillman Cancer Center - Part of Frick Hospital
Mount Pleasant, Pennsylvania, 15666
Site Contact
Site Public Contact
[email protected]
412-389-5208
Status
Recruiting
Address
Arnold Palmer Cancer Center Medical Oncology Norwin
N. Huntingdon, Pennsylvania, 15642
Site Contact
Site Public Contact
[email protected]
412-389-5208
Status
Recruiting
Address
UPMC Cancer Center-Natrona Heights
Natrona Heights, Pennsylvania, 15065
Site Contact
Site Public Contact
724-230-3030
Status
Recruiting
Address
UPMC Hillman Cancer Center - New Castle
New Castle, Pennsylvania, 16105
Site Contact
Site Public Contact
[email protected]
412-389-5208
Status
Recruiting
Address
ECOG-ACRIN Cancer Research Group
Philadelphia, Pennsylvania, 19103
Site Contact
Aarti Bhatia
[email protected]
Status
Recruiting
Address
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107
Site Contact
Site Public Contact
[email protected]
215-600-9151
Status
Recruiting
Address
Jefferson Torresdale Hospital
Philadelphia, Pennsylvania, 19114
Site Contact
Site Public Contact
[email protected]
215-600-9151
Status
Recruiting
Address
Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212
Site Contact
Site Public Contact
877-284-2000
Status
Recruiting
Address
UPMC-Saint Margaret
Pittsburgh, Pennsylvania, 15215
Site Contact
Site Public Contact
412-784-4900
Status
Recruiting
Address
UPMC-Mercy Hospital
Pittsburgh, Pennsylvania, 15219
Site Contact
Site Public Contact
800-533-8762
Status
Recruiting
Address
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania, 15232
Site Contact
Site Public Contact
412-647-8073
Status
Recruiting
Address
UPMC-Passavant Hospital
Pittsburgh, Pennsylvania, 15237
Site Contact
Site Public Contact
412-367-6454
Status
Recruiting
Address
UPMC-Saint Clair Hospital Cancer Center
Pittsburgh, Pennsylvania, 15243
Site Contact
Site Public Contact
412-502-3920
Status
Recruiting
Address
UPMC Cancer Center at UPMC Northwest
Seneca, Pennsylvania, 16346
Site Contact
Site Public Contact
814-676-7900
Status
Recruiting
Address
UPMC Cancer Center-Uniontown
Uniontown, Pennsylvania, 15401
Site Contact
Site Public Contact
[email protected]
Status
Recruiting
Address
UPMC Cancer Center-Washington
Washington, Pennsylvania, 15301
Site Contact
Site Public Contact
[email protected]
Status
Recruiting
Address
UPMC West Mifflin-Cancer Center Jefferson
West Mifflin, Pennsylvania, 15122
Site Contact
Site Public Contact
412-653-8100
Status
Recruiting
Address
Divine Providence Hospital
Williamsport, Pennsylvania, 17754
Site Contact
Site Public Contact
[email protected]
Status
Recruiting
Address
Asplundh Cancer Pavilion
Willow Grove, Pennsylvania, 19090
Site Contact
Site Public Contact
[email protected]
215-600-9151
Status
Recruiting
Address
UPMC Memorial
York, Pennsylvania, 17408
Site Contact
Site Public Contact
717-724-6760
Status
Recruiting
Address
Smilow Cancer Hospital Care Center - Westerly
Westerly, Rhode Island, 02891
Site Contact
Site Public Contact
[email protected]
203-785-5702
Status
Active, not recruiting
Address
Thompson Cancer Survival Center
Knoxville, Tennessee, 37916
Status
Active, not recruiting
Address
Thompson Cancer Survival Center - West
Knoxville, Tennessee, 37932
Status
Active, not recruiting
Address
Thompson Oncology Group-Lenoir City
Lenoir City, Tennessee, 37772
Status
Recruiting
Address
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232
Site Contact
Site Public Contact
800-811-8480
Status
Active, not recruiting
Address
Thompson Oncology Group-Oak Ridge
Oak Ridge, Tennessee, 37830
Status
Suspended
Address
Dartmouth Cancer Center - North
Saint Johnsbury, Vermont, 05819
Status
Recruiting
Address
West Virginia University Charleston Division
Charleston, West Virginia, 25304
Site Contact
Site Public Contact
304-388-9944
Status
Recruiting
Address
ProHealth D N Greenwald Center
Mukwonago, Wisconsin, 53149
Site Contact
Site Public Contact
[email protected]
Status
Recruiting
Address
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, 53066
Site Contact
Site Public Contact
262-928-7878
Status
Recruiting
Address
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin, 53188
Site Contact
Site Public Contact
[email protected]
262-928-5539
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