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Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

Study Purpose

This phase II/III trial studies how well sentinel lymph node biopsy works and compares sentinel lymph node biopsy surgery to standard neck dissection as part of the treatment for early-stage oral cavity cancer. Sentinel lymph node biopsy surgery is a procedure that removes a smaller number of lymph nodes from your neck because it uses an imaging agent to see which lymph nodes are most likely to have cancer. Standard neck dissection, such as elective neck dissection, removes many of the lymph nodes in your neck. Using sentinel lymph node biopsy surgery may work better in treating patients with early-stage oral cavity cancer compared to standard elective neck dissection.

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

 No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

 Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

  • - PRIOR TO STEP 1 REGISTRATION INCLUSION: - Pathologically (histologically or cytologically) proven diagnosis of squamous cell carcinoma of the oral cavity, including the oral (mobile) tongue, floor of mouth (FOM), mucosal lip, buccal mucosa, lower alveolar ridge, upper alveolar ridge, retromolar gingiva (retromolar trigone; RMT), or hard palate prior to registration.
  • - Appropriate stage for study entry (T1-2N0M0; American Joint Committee on Cancer [AJCC] 8th edition [ed.
]) based on the following diagnostic workup:
  • - History/physical examination within 42 days prior to registration.
  • - Imaging of head and neck within 42 days prior to registration.
  • - PET/CT scan or contrast neck CT scan, or gadolinium-enhanced neck magnetic resonance imaging (MRI) or lateral and central neck ultrasound; diagnostic quality CT is preferred and highly recommended for the PET/CT when possible.
  • - Imaging of chest within 42 days prior to registration; chest x-ray, CT chest scan (with or without contrast) or PET/CT (with or without contrast) - Surgical assessment within 42 days prior to registration.
Patient must be a candidate for surgical intervention with sentinel lymph node (SLN) biopsy and potential completion neck dissection (CND) or elective neck dissection (END)
  • - Surgical resection of the primary tumor will occur through a transoral approach with anticipation of resection free margins.
  • - Zubrod performance status 0-2 within 42 days prior to registration.
  • - For women of child-bearing potential, negative serum or urine pregnancy test within 42 days prior to registration.
  • - The patient or a legally authorized representative must provide study-specific informed consent prior to study entry.
  • - Only patients who are able to read and understand English are eligible to participate as the mandatory patient reported NDII tool is only available in this language.
  • - PRIOR TO STEP 2 RANDOMIZATION: - FDG PET/CT required prior to step 2.
Note: FDG PET/CT done prior to step 1 can be submitted for central review.
  • - PET/CT node negative patients, determined by central read, will proceed to randomization.
  • - PET/CT node positive patients will go off study, but will be entered in a registry and data will be collected to record the pathological outcome of neck nodes for diagnostic imaging assessment and future clinical trial development.
  • - NOTE: All FDG PET/CT scans must be performed on an American College of Radiology (ACR) accredited scanner (or similar accrediting organization) - The patient must complete NDII prior to step 2 registration.

Exclusion Criteria:

  • - PRIOR TO STEP 1 REGISTRATION EXCLUSION: - Definitive clinical or radiologic evidence of regional (cervical) and/or distant metastatic disease.
  • - Prior non-head and neck invasive malignancy (except non-melanomatous skin cancer, including effectively treated basal cell or squamous cell skin cancer, or carcinoma in situ of the breast or cervix) unless disease free for ≥ 2 years.
  • - Diagnosis of head and neck squamous cell carcinoma (SCC) in the oropharynx, nasopharynx, hypopharynx, and larynx.
  • - Unable or unwilling to complete NDII (baseline only) - Prior systemic chemotherapy for the study cancer; note that prior chemotherapy for a different cancer is allowable.
  • - Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields.
  • - Patient with severe, active co-morbidity that would preclude an elective or completion neck dissection.
  • - Pregnancy and breast-feeding mothers.
  • - Incomplete resection of oral cavity lesion with a positive margin; however, an excisional biopsy is permitted.
  • - Prior surgery involving the lateral neck, including neck dissection or gross injury to the neck that would preclude surgical dissection for this trial.
Prior thyroid and central neck surgery is permissible; biopsy is permitted. Note: Borderline suspicious nodes that are ≥ 1 cm with radiographic finding suggestive of NOT malignant should be biopsied using ultrasound-guided (U/S-guided) fine-needle aspiration (FNA) biopsy.
  • - Underlying or documented history of hematologic malignancy (e.g., chronic lymphocytic leukemia [CLL]) or other active disease capable of causing lymphadenopathy (sarcoidosis or untreated mycobacterial infection) - Actively receiving systemic cytotoxic chemotherapy, immunosuppressive, anti-monocyte or immunomodulatory therapy.
- Currently participating in another investigational therapeutic trial

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

 NCT04333537
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

 Phase 2/Phase 3
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

 NRG Oncology
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

 Stephen Y Lai
Principal Investigator Affiliation NRG Oncology
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

 Other, NIH
Overall Status Recruiting
Countries Canada, United States
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

 Buccal Mucosa Squamous Cell Carcinoma, Floor of Mouth Squamous Cell Carcinoma, Gingival Squamous Cell Carcinoma, Hard Palate Squamous Cell Carcinoma, Lip Squamous Cell Carcinoma, Lower Alveolar Ridge Squamous Cell Carcinoma, Oral Cavity Squamous Cell Carcinoma, Retromolar Trigone Squamous Cell Carcinoma, Stage I Lip and Oral Cavity Cancer AJCC v8, Stage II Lip and Oral Cavity Cancer AJCC v8, Tongue Squamous Cell Carcinoma, Upper Alveolar Ridge Squamous Cell Carcinoma
Additional Details

PRIMARY OBJECTIVES:

  • I. To determine if patient-reported neck and shoulder function and related quality of life (QOL) at 6 months after surgery using the Neck Dissection Impairment Index (NDII) is superior with sentinel lymph node (SLN) biopsy compared to elective neck dissection (END) for treatment of early-stage oral cavity squamous cell carcinoma (OCSCC) (cT1-2N0).
(Phase II)
  • II. To determine if disease-free survival (DFS) is non-inferior with SLN biopsy compared to END for treatment of early-stage OCSCC (cT1-2N0).
(Phase III)
  • III. To determine if patient-reported neck and shoulder function and related QOL at 6 months after surgery using NDII is superior with SLN biopsy compared to END for treatment of early-stage OCSCC (cT1-2N0).
(Phase III) SECONDARY OBJECTIVES:
  • I. To compare patterns of failure (local-regional relapse and distant metastasis) between surgical arms.
  • II. To measure and compare overall survival (OS) between surgical arms.
  • III. To measure and compare the toxicity of the two surgical arms.
  • IV. To measure longitudinal patient-reported neck and shoulder function and related QOL between surgical arms, using the following instruments: IVa.
Neck Dissection Impairment Index (NDII). IVb. Abbreviated Disabilities of the Arm, Shoulder and Hand (QuickDASH). IVc. Functional Assessment of Cancer Therapy-Head and Neck (FACT-H&N).
  • V. To assess the length of hospitalization, post-operative drain placement, and operative morbidity between arms.
  • VI. To estimate the negative predictive rate of fludeoxyglucose F-18 (FDG)-positron emission tomography/computed tomography (PET/CT) for N0 neck in patients with T1 and T1-2 oral cavity squamous cell cancer (OCSCC) patients in the END arm.
  • VII. To assess nodal metastases rates between arms.
  • VIII. To assess the pathologic false omission rate (FOR) in the SLN biopsy arm.
  • IX. To determine if patient-reported neck and shoulder function and related QOL at 6 months after surgery using the NDII is superior with the SLN biopsy compared to the END in low-risk patients.
EXPLORATORY OBJECTIVES:
  • I. To compare changes in patient-reported outcomes (European Quality of Life Five Dimension Five Level Scale Questionnaire [EQ-5D-5L]) between surgical arms.
  • II. To collect biospecimens for future translational science studies.
  • III. To assess the DFS between arms in low-risk patients.
OUTLINE: Patients are randomized to 1 of 2 groups. GROUP I: Patients receive an imaging agent via injection and undergo planar imaging and single photo emission computed tomography/computed tomography (SPECT/CT) over 1-2 hours. Patients then undergo SLN biopsy. GROUP II: Patients undergo standard END. After completion of study treatment, patients are followed up 3 weeks after surgery, every 3 months for year 1, every 4 months for year 2, every 6 months for year 3, then yearly thereafter.

Arms & Interventions

Arms

Experimental: Sentinel Lymph Node (SLN) Biopsy

Patients receive an imaging agent via injection and undergo planar imaging and SPECT/CT over 1-2 hours. Patients then undergo SLN biopsy.

Active Comparator: Elective Neck Dissection (END)

Patients undergo standard END.

Interventions

Procedure: - Computed Tomography (CT)

Undergo SPECT/CT scan

Drug: - Imaging Agent

Receive imaging agent via injection

Procedure: - Neck Dissection

Undergo standard elective neck dissection

Procedure: - Planar Imaging

Undergo planar imaging

Procedure: - Sentinel Lymph Node Biopsy

Undergo SLN biopsy

Procedure: - Single Photon Emission Computed Tomography

Undergo SPECT/CT scan

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Tucson, Arizona

Status

Recruiting

Address

Banner University Medical Center - Tucson

Tucson, Arizona, 85719

Site Contact

Site Public Contact

[email protected]

Tucson, Arizona

Status

Recruiting

Address

University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719

Site Contact

Site Public Contact

[email protected]

Little Rock, Arkansas

Status

Recruiting

Address

University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205

Site Contact

Site Public Contact

501-686-8274

City of Hope Comprehensive Cancer Center, Duarte, California

Status

Recruiting

Address

City of Hope Comprehensive Cancer Center

Duarte, California, 91010

Site Contact

Site Public Contact

[email protected]

800-826-4673

UC San Diego Moores Cancer Center, La Jolla, California

Status

Recruiting

Address

UC San Diego Moores Cancer Center

La Jolla, California, 92093

Site Contact

Site Public Contact

[email protected]

858-822-5354

Stanford Cancer Institute Palo Alto, Palo Alto, California

Status

Recruiting

Address

Stanford Cancer Institute Palo Alto

Palo Alto, California, 94304

Site Contact

Site Public Contact

[email protected]

650-498-7061

Sacramento, California

Status

Active, not recruiting

Address

University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817

Stanford Cancer Center South Bay, San Jose, California

Status

Recruiting

Address

Stanford Cancer Center South Bay

San Jose, California, 95124

Site Contact

Site Public Contact

[email protected]

650-498-7061

Yale University, New Haven, Connecticut

Status

Recruiting

Address

Yale University

New Haven, Connecticut, 06520

Site Contact

Site Public Contact

[email protected]

203-785-5702

Trumbull, Connecticut

Status

Recruiting

Address

Smilow Cancer Hospital Care Center-Trumbull

Trumbull, Connecticut, 06611

Site Contact

Site Public Contact

[email protected]

203-785-5702

Coral Gables, Florida

Status

Recruiting

Address

UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, 33146

Site Contact

Site Public Contact

305-243-2647

Deerfield Beach, Florida

Status

Recruiting

Address

UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442

Site Contact

Site Public Contact

305-243-2647

Miami, Florida

Status

Recruiting

Address

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136

Site Contact

Site Public Contact

305-243-2647

Emory University Hospital Midtown, Atlanta, Georgia

Status

Recruiting

Address

Emory University Hospital Midtown

Atlanta, Georgia, 30308

Site Contact

Site Public Contact

888-946-7447

Atlanta, Georgia

Status

Recruiting

Address

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322

Site Contact

Site Public Contact

404-778-1868

Northwestern University, Chicago, Illinois

Status

Recruiting

Address

Northwestern University

Chicago, Illinois, 60611

Site Contact

Site Public Contact

[email protected]

312-695-1301

Rush University Medical Center, Chicago, Illinois

Status

Recruiting

Address

Rush University Medical Center

Chicago, Illinois, 60612

Site Contact

Site Public Contact

[email protected]

312-942-5498

Springfield, Illinois

Status

Suspended

Address

Southern Illinois University School of Medicine

Springfield, Illinois, 62702

Memorial Medical Center, Springfield, Illinois

Status

Suspended

Address

Memorial Medical Center

Springfield, Illinois, 62781

Iowa City, Iowa

Status

Recruiting

Address

University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242

Site Contact

Site Public Contact

800-237-1225

University of Kansas Cancer Center, Kansas City, Kansas

Status

Recruiting

Address

University of Kansas Cancer Center

Kansas City, Kansas, 66160

Site Contact

Site Public Contact

[email protected]

913-588-3671

Westwood, Kansas

Status

Recruiting

Address

University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205

Site Contact

Site Public Contact

[email protected]

913-588-3671

Lexington, Kentucky

Status

Active, not recruiting

Address

University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536

Louisville, Kentucky

Status

Suspended

Address

The James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, 40202

LSU Health Sciences Center at Shreveport, Shreveport, Louisiana

Status

Recruiting

Address

LSU Health Sciences Center at Shreveport

Shreveport, Louisiana, 71103

Site Contact

Site Public Contact

[email protected]

318-813-1404

Boston Medical Center, Boston, Massachusetts

Status

Suspended

Address

Boston Medical Center

Boston, Massachusetts, 02118

Ann Arbor, Michigan

Status

Recruiting

Address

University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109

Site Contact

Site Public Contact

800-865-1125

Detroit, Michigan

Status

Recruiting

Address

Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201

Site Contact

Site Public Contact

[email protected]

313-576-9790

Henry Ford Hospital, Detroit, Michigan

Status

Recruiting

Address

Henry Ford Hospital

Detroit, Michigan, 48202

Site Contact

Site Public Contact

[email protected]

313-916-3721

Weisberg Cancer Treatment Center, Farmington Hills, Michigan

Status

Recruiting

Address

Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334

Site Contact

Site Public Contact

[email protected]

313-576-9790

Omaha, Nebraska

Status

Recruiting

Address

Nebraska Cancer Specialists/Oncology Hematology West PC - MECC

Omaha, Nebraska, 68114

Site Contact

Site Public Contact

402-334-4773

Nebraska Methodist Hospital, Omaha, Nebraska

Status

Recruiting

Address

Nebraska Methodist Hospital

Omaha, Nebraska, 68114

Site Contact

Site Public Contact

402-354-5144

Oncology Associates PC, Omaha, Nebraska

Status

Recruiting

Address

Oncology Associates PC

Omaha, Nebraska, 68114

Site Contact

Site Public Contact

[email protected]

402-354-5860

Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey

Status

Recruiting

Address

Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920

Site Contact

Site Public Contact

212-639-7592

Saint Barnabas Medical Center, Livingston, New Jersey

Status

Recruiting

Address

Saint Barnabas Medical Center

Livingston, New Jersey, 07039

Site Contact

Site Public Contact

[email protected]

973-322-2934

Memorial Sloan Kettering Monmouth, Middletown, New Jersey

Status

Recruiting

Address

Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748

Site Contact

Site Public Contact

212-639-7592

Memorial Sloan Kettering Bergen, Montvale, New Jersey

Status

Recruiting

Address

Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645

Site Contact

Site Public Contact

212-639-7592

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey

Status

Recruiting

Address

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903

Site Contact

Site Public Contact

732-235-7356

Roswell Park Cancer Institute, Buffalo, New York

Status

Recruiting

Address

Roswell Park Cancer Institute

Buffalo, New York, 14263

Site Contact

Site Public Contact

[email protected]

800-767-9355

Memorial Sloan Kettering Commack, Commack, New York

Status

Recruiting

Address

Memorial Sloan Kettering Commack

Commack, New York, 11725

Site Contact

Site Public Contact

212-639-7592

Memorial Sloan Kettering Westchester, Harrison, New York

Status

Recruiting

Address

Memorial Sloan Kettering Westchester

Harrison, New York, 10604

Site Contact

Site Public Contact

212-639-7592

Lake Success, New York

Status

Active, not recruiting

Address

Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042

NYU Winthrop Hospital, Mineola, New York

Status

Recruiting

Address

NYU Winthrop Hospital

Mineola, New York, 11501

Site Contact

Site Public Contact

[email protected]

212-263-4432

Long Island Jewish Medical Center, New Hyde Park, New York

Status

Active, not recruiting

Address

Long Island Jewish Medical Center

New Hyde Park, New York, 11040

New York, New York

Status

Recruiting

Address

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016

Site Contact

Site Public Contact

[email protected]

Lenox Hill Hospital, New York, New York

Status

Active, not recruiting

Address

Lenox Hill Hospital

New York, New York, 10021

Manhattan Eye Ear and Throat Hospital, New York, New York

Status

Active, not recruiting

Address

Manhattan Eye Ear and Throat Hospital

New York, New York, 10065

Memorial Sloan Kettering Cancer Center, New York, New York

Status

Recruiting

Address

Memorial Sloan Kettering Cancer Center

New York, New York, 10065

Site Contact

Site Public Contact

212-639-7592

Memorial Sloan Kettering Nassau, Uniondale, New York

Status

Recruiting

Address

Memorial Sloan Kettering Nassau

Uniondale, New York, 11553

Site Contact

Site Public Contact

212-639-7592

Sanford Broadway Medical Center, Fargo, North Dakota

Status

Suspended

Address

Sanford Broadway Medical Center

Fargo, North Dakota, 58122

Sanford Roger Maris Cancer Center, Fargo, North Dakota

Status

Suspended

Address

Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122

Cleveland Clinic Foundation, Cleveland, Ohio

Status

Recruiting

Address

Cleveland Clinic Foundation

Cleveland, Ohio, 44195

Site Contact

Site Public Contact

[email protected]

866-223-8100

Columbus, Ohio

Status

Recruiting

Address

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210

Site Contact

Site Public Contact

[email protected]

800-293-5066

Oklahoma City, Oklahoma

Status

Recruiting

Address

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104

Site Contact

Site Public Contact

[email protected]

405-271-8777

Clackamas Radiation Oncology Center, Clackamas, Oregon

Status

Recruiting

Address

Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015

Site Contact

Site Public Contact

[email protected]

503-215-2614

Providence Newberg Medical Center, Newberg, Oregon

Status

Suspended

Address

Providence Newberg Medical Center

Newberg, Oregon, 97132

Providence Portland Medical Center, Portland, Oregon

Status

Recruiting

Address

Providence Portland Medical Center

Portland, Oregon, 97213

Site Contact

Site Public Contact

[email protected]

503-215-2614

Providence Saint Vincent Medical Center, Portland, Oregon

Status

Recruiting

Address

Providence Saint Vincent Medical Center

Portland, Oregon, 97225

Site Contact

Site Public Contact

[email protected]

503-215-2614

Geisinger Medical Center, Danville, Pennsylvania

Status

Recruiting

Address

Geisinger Medical Center

Danville, Pennsylvania, 17822

Site Contact

Site Public Contact

[email protected]

570-271-5251

Hershey, Pennsylvania

Status

Suspended

Address

Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

Status

Recruiting

Address

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107

Site Contact

Site Public Contact

[email protected]

215-600-9151

Fox Chase Cancer Center, Philadelphia, Pennsylvania

Status

Active, not recruiting

Address

Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111

Pittsburgh, Pennsylvania

Status

Recruiting

Address

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232

Site Contact

Site Public Contact

412-647-8073

UPMC-Shadyside Hospital, Pittsburgh, Pennsylvania

Status

Recruiting

Address

UPMC-Shadyside Hospital

Pittsburgh, Pennsylvania, 15232

Site Contact

Site Public Contact

412-621-2334

Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota

Status

Recruiting

Address

Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, 57104

Site Contact

Site Public Contact

[email protected]

605-312-3320

Avera Cancer Institute, Sioux Falls, South Dakota

Status

Recruiting

Address

Avera Cancer Institute

Sioux Falls, South Dakota, 57105

Site Contact

Site Public Contact

[email protected]

605-322-3095

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota

Status

Recruiting

Address

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134

Site Contact

Site Public Contact

[email protected]

605-312-3320

Methodist Hospital, Memphis, Tennessee

Status

Recruiting

Address

Methodist Hospital

Memphis, Tennessee, 38104

Site Contact

Site Public Contact

901-516-2579

Memphis, Tennessee

Status

Recruiting

Address

University of Tennessee Health Science Center

Memphis, Tennessee, 38163

Site Contact

Site Public Contact

[email protected]

901-683-0055

Nashville, Tennessee

Status

Recruiting

Address

Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232

Site Contact

Site Public Contact

800-811-8480

MD Anderson in The Woodlands, Conroe, Texas

Status

Recruiting

Address

MD Anderson in The Woodlands

Conroe, Texas, 77384

Site Contact

Site Public Contact

[email protected]

866-632-6789

Houston, Texas

Status

Recruiting

Address

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030

Site Contact

Site Public Contact

[email protected]

713-798-1354

M D Anderson Cancer Center, Houston, Texas

Status

Recruiting

Address

M D Anderson Cancer Center

Houston, Texas, 77030

Site Contact

Site Public Contact

[email protected]

877-632-6789

Michael E DeBakey VA Medical Center, Houston, Texas

Status

Recruiting

Address

Michael E DeBakey VA Medical Center

Houston, Texas, 77030

Site Contact

Site Public Contact

800-553-2278

MD Anderson West Houston, Houston, Texas

Status

Recruiting

Address

MD Anderson West Houston

Houston, Texas, 77079

Site Contact

Site Public Contact

[email protected]

877-632-6789

MD Anderson League City, League City, Texas

Status

Recruiting

Address

MD Anderson League City

League City, Texas, 77573

Site Contact

Site Public Contact

[email protected]

877-632-6789

MD Anderson in Sugar Land, Sugar Land, Texas

Status

Recruiting

Address

MD Anderson in Sugar Land

Sugar Land, Texas, 77478

Site Contact

Site Public Contact

[email protected]

877-632-6789

Berlin, Vermont

Status

Recruiting

Address

Central Vermont Medical Center/National Life Cancer Treatment

Berlin, Vermont, 05602

Site Contact

Site Public Contact

802-225-5400

University of Vermont Medical Center, Burlington, Vermont

Status

Recruiting

Address

University of Vermont Medical Center

Burlington, Vermont, 05401

Site Contact

Site Public Contact

[email protected]

802-656-4101

Burlington, Vermont

Status

Recruiting

Address

University of Vermont and State Agricultural College

Burlington, Vermont, 05405

Site Contact

Site Public Contact

[email protected]

802-656-8990

International Sites

Toronto, Ontario, Canada

Status

Recruiting

Address

University Health Network-Princess Margaret Hospital

Toronto, Ontario, M5G 2M9

Site Contact

Site Public Contact

[email protected]

416-946-4501

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