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Optical Sensor for Photodynamic Detection of Oral Pathology
Study Purpose
Overall objective of this work is to develop better ways of detecting, diagnosing and measuring oral diseases and structures using light and optical approaches. All different areas of the mouth will be imaged, including healthy, diseased, dysplastic and malignant, as well as oral biofilm, and the imaging data compared against conventional diagnostic approaches such clinical and histopathological and molecular evaluations to
- (1) gain a better
understanding of processes involved in oral pathology and (2) develop a combined patient
specific, non-invasive method for the detection, diagnosis and screening of oral pathology
and biofilm.
Thus our goal is to identify and evaluate microstructural, metabolic, vascular, protein, genomic and metabolomics biomarkers of oral pathology can be used to detect, predict and map oral pathology, especially neoplasia. We are recruiting patients with a wide range of oral conditions including plaque, dry mouth, toothache, root canal treatments, gum disease, oral sores, dysplasia and cancer, autoimmune conditions and others as well as healthy control subjects. We will use a range of non-invasive imaging modalities to obtain information on the ways in which the oral health status affects optical properties, and determine means of detecting and quantifying these factors.. Imaging modalities to be utilized include: 1. Coherence and Doppler Tomography. 2. Laser Speckle Imaging. 3. Various forms of Spectroscopy. 4. FluorescenceRecruitment Criteria
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.
An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.
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Inclusion Criteria:
Exclusion Criteria:
- - Pregnant or breastfeeding.
- Immune compromised individualsTrial Details
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.
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The disease, disorder, syndrome, illness, or injury that is being studied.
Purpose of the research is to identify optical predictors and biomarkers of health and disease. Hypothesis: microstructural, metabolic, vascular, protein, genomic and metabolomics biomarkers of oral pathology can be used to detect, predict and map oral pathology, especially neoplasia. Researchers of the Beckman Laser Institute (BLI) have developed many non-invasive imaging modalities for assessment of oral tissue. This protocol will allow data acquisition with these multiple modalities to allow validation of data. Imaging modalities to be utilized include: 1. Coherence and Doppler Tomography (OCT) 2. Laser Speckle Imaging (LSI) 3. Photon Migration Spectroscopy (PMS) 4. Autofluorescence Imaging. In addition, saliva samples from the patients will be analyzed and the resulting data regarding the dysregulation in the activities of genes, proteins and other molecules will be correlated with findings from different imaging systems with respect to the stage of oral carcinogenesis.
Arms
Other: Oral tissue
Imaging of oral structures and pathologies
Interventions
Device: - detection of oral pathology
detection of oral pathology
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Status
Recruiting
Address
Beckman Laser Institute and Medical Clinic
Irvine, California, 92612
Site Contact
Nicole Wakida, PhD
[email protected]
949-824-4360
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